Mick Emandi & Dr. Greg Carter

In this episode, Mick Emandi and Dr. Greg Carter explain the evolution from PRP to stem cells to exosomes — and now to regenerative signaling factors (RSFs). They explore molecular hydrogen therapy, mitochondrial optimization, and the science behind placental-derived signaling molecules.

It’s a bold conversation about functional medicine, biological age, and what the future of healthcare might look like.

The Conversation Covers:

The difference between traditional medicine and functional medicine

The concept of biological vs. chronological age

Molecular hydrogen as a proposed “essential nutrient”

The four generations of regenerative medicine (PRP, stem cells, exosomes, and RSFs)

The biological theory behind regenerative signaling factors

How placental-derived signaling molecules are used in current protocols

Why RSFs are presented as the next step beyond stem cells and exosomes

Telehealth delivery and national access to treatment

The episode explores ambitious claims about optimizing mitochondrial function, reducing oxidative stress, and supporting tissue repair — while also raising questions about emerging therapies and their long-term evidence base.

This is a wide-ranging conversation about aging, innovation, medical evolution, and the search for better outcomes beyond standard care.

Key Topics Discussed

1️⃣ From Medical Marijuana to Regenerative Medicine

Florida’s early legalization of medical marijuana

Building an integrative practice

Transition into functional and regenerative medicine

2️⃣ Functional Medicine vs Traditional Care

Traditional care: stabilization and survival

Functional care: optimization and performance

Lifestyle foundations: diet, exercise, baseline health

3️⃣ Biological Age vs Chronological Age

Measuring aging through biomarkers

Modifying health trajectories

The idea of slowing or reversing markers of aging

4️⃣ Molecular Hydrogen Therapy

Mitochondria and ATP production

Oxidative stress and free radicals

Hydrogen inhalation as a proposed fuel source

Claims of ~3,000 supporting studies

Paleolithic microbiome comparison

5️⃣ The Four Generations of Regenerative Medicine

1. PRP (Platelet-Rich Plasma)
Early regenerative strategy with modest results.

2. Stem Cells
Initially believed to differentiate into tissue.
Shift toward understanding signaling functions.

3. Exosomes
RNA-based signaling particles derived from stem cells.

4. Regenerative Signaling Factors (RSFs)
Acellular signaling molecules harvested from placental tissue.
Proposed to avoid risks associated with live-cell therapies.
Claimed to draw from all six placental regions rather than a single source.

6️⃣ Stem Cells vs RSFs — The Claimed Differences

Stem cells as “delivery vehicles”

Paracrine signaling as the active mechanism

Concerns raised about DNA/RNA risks

RSFs described as more targeted and shelf-stable

7️⃣ Clinical Indications Mentioned

Joint pain and orthopedic issues

Neurodegenerative conditions

Cardiovascular and autoimmune conditions

Systemic inflammation

8️⃣ Telehealth Delivery Model

National consultations

At-home protocols

Objective baseline testing

Listener Takeaways

Regenerative medicine is evolving rapidly

Many therapies focus on signaling, not cell replacement

Molecular hydrogen therapy is being positioned as foundational

RSFs are being presented as the next phase beyond stem cells

Evidence levels and long-term data remain key considerations

Disclaimer

This episode contains discussion of emerging medical therapies. Listeners should consult qualified medical professionals before making healthcare decisions. The views expressed are those of the guests and are not medical advice.